Turkish Abstract Abstract Article PDF Similar Articles Mail to Author

¹Gazi Üniversitesi, Göz Hastalıkları A.D., Ankara Doç. Dr.
²Rize Üniversitesi, Göz Hastalıkları A.D., Rize, Yard. Doç. Dr.
³Gazi Üniversitesi, Göz Hastalıkları A.D., Ankara, Asis.Dr.
⁴Gazi Üniversitesi, Göz Hastalıkları A.D., Ankara, Prof. Dr. Purpose: To report the outcome of combined verteporfin photodynamic therapy (PDT) and intravitreal bevacizumab (IVB) for the treatment of choroidal neovascularization (CNV) due to pathologic myopia.
Materials and Methods: The reports of the patients with CNV secondary to pathologic myopia who received PDT and 2.5 mg of IVB were reviewed. All of the eyes were examined with optic coherence tomography and fluorescein anjiography in addition to Snellen visual acuity (VA) assessment and total ophthalmologic examination both before and after treatment. An activity score (AS) was given to each lesion during all visits. Retreatments were done if the AS is at least 7 during the control visits.
Results: Six patients were included. The mean logMAR VA was 1.30 before treatment, 0.86 at the last visit (p<0.05). Mean improvement in VA was 2 (range, -2 to 4) Snellen lines. The mean AS was significantly lower than the baseline at each visit (p<0.05). Initial foveal thickness improved from 394.4±222.7 μm to 175.4±25.4 μm after the last follow-up (p<0.05). The mean number of PDT/patient was 1.7 and that of IVB was 2.5 during the 28 months of a mean follow-up.
Conclusion: The results of this study suggest that PDT combined with IVB seems to be effective in treating myopic CNV by reducing retreatment needs and improving visual acuity. Keywords : Pathologic myopia, photodynamic therapy, bevacizumab, combination therapy