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¹M.D. Associate Professor, Dokuz Eylül University Faculty of Medicine, Department of Ophthalmology, İzmir/TURKEY
²M.D. Professor, Dokuz Eylül University Faculty of Medicine, Department of Ophthalmology, İzmir/TURKEY This review describes the ocular manifestations of patients with sickle cell disease. Sickle cell disease is one of the most common genetic disease worldwide. The pathophysiology of the disease is not limited to abnormal red blood cells. Endothelial activation, inflammation, and oxidative stress have an effect on the sickle cell disease. The most significant ocular changes occur in the retina. Keywords : Erythrocyte, sickle cell disease, oxidative stres