2M.D. Professor, Necmettin Erbakan University Faculty of Medicine, Department of Ophthalmology, Konya/TURKEY Purpose: To construct standard conditions for pattern electroretinogram (PERG) recordings and to investigate normal values in healthy individuals.
Material and Methods: 226 eyes of 113 healthy participants (76 females and 37 males) with no ocular and systemic disease were included in the study after objective refraction, best corrected visual acuity measurements and anterior segment and fundus examinations using biomicroscopy. The PERG recordings were made using Roland-Consult RETIPORT (Germany). Latencies and amplitudes of P50 and N95 components were recorded. Data was evaluated in different age groups.
Results: The average age of participants was 35.95±14.8 years (males: 38.46±17.10, females: 34.72±13.59 years). There was no statistically significant difference between males and females in latency and amplitudes of PERG components (p>0.05). The latencies of P50 and N95 showed a weak positive correlation with age (p<0.05). The amplitude values of P50 and N95 showed a negative correlation with age being more prominent in the former (p<0.05). No correlation was found with age in N95/P50 ratio (p>0.05). A strong positive correlation was identified with P50 and N95 amplitude values in binary correlation analysis. P50 and N95 amplitudes showed a significant fall after the 3rd decade, the values were similar to each other in the 4th , 5th and 6th decades and the latency of N95 were markedly increased from 3rd to 6th decade.
Conclusions: The statistically non-significant PERG values in male and female subjects is important for the determination of normal values. The decrease in P50 and N95 amplitude with age especially after the 3rd decade and the increase in latency of the N95, implies to consider the age factor in PERG evaluation. Since the N95/P50 ratio is not correlated with age, it would be more correct to evaluate the amplitude ratios instead of amplitudes.
Keywords : Normal PERG values, pattern electroretinography, age