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Uz. Dr., Konya Eğitim ve Araştırma Hastanesi, Göz Hastalıkları Kliniği, Konya, Türkiye Retinal venous occlusive disease is the second most common retinal vascular disorder following diabetic retinopathy.The exact pathogenesis and risk factors of RVO in younger patients?most of whom are otherwise healthy are still poorly understood. This case report shows a varenicline (Champix, Pfizer, Mumbai, India)-associated acute thrombotic CRVO in a patient without previous history of systemic inflammation or vascular occlusive disease. Keywords : Varenicline, Thrombosis, Central Retinal Vein Occlusion