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¹SSK Ankara Hastanesi 2. Göz Kliniği,
²Hacettepe Üniversitesi Tıp Fakültesi Farmakoloji ABD This study was conducted to assess the subretinal fluid (SRF) penetration of ofloxacin and to investigate the levels of drug following topical or oral administration alone and after combined topical and oral administration and to learn ideal application way for ofloxacin. Thirty-one patients undergoing conventional retinal reattachment surgery were divided into three groups: Nine patients received 2 drops of 0.3% ophthalmic solution of ofloxacin every 30 minutes for 3 hours and every 60 minutes for the next 3 hours, 11 patients received a single oral dose of 400 mg ofloxacin 8 hours before surgery, and other 11 patients received combined topical and oral drug administration. SRF samples were collected and analysed for ofloxacin levels by a method using high-performance liquid chromatography. Mean SRF level of ofloxacin was 0.39 ± 0.06 µg/ml after topical, 1.60 ± 0.26µg/ml after oral and 2.47 ± 0.38 µg/ml after combined ofloxacin administration. SRF levels of the drug after oral and combined administration were significantly higher than that after topical administration (P= .0002 and P= .0002, respectively) while there was no significant difference among oral and combined administration (P= .0844). Ocular bioavailabillity of ofoxacin in SRF after oral and combined administration is equivalent when the drug was applied as described above. Topical ofloxacin can penetrate SRF, however this level does not exceed the MIC so for most of certain bacterial species that frequently cause intraocular infections. The addition of oral ofloxacin to topical therapy increased SRF penetration 6 fold in this study. Keywords : fluoroquinolone, ofloxacin, subretinal fluid