Materials and Methods: The records of 46 patients with acute CSC were retrospectively evaluated. After exclusion, 24 eyes of 24 patients were analyzed. The relationship between anatomical& functional recovery and the height of subretinal fluid (SRF) in the center of the fovea, the outer nuclear layer thickness (ONLT), the existence of pathology in retinal pigment epithelium (RPE), the volume of subretinal fluid (SRFV), and base width of subretinal fluid (SRFBW) were evaluated through spectral-domain optical coherence tomography (SD-OCT).

Results: The mean age of the patients was 46.2 ± 8.8 years (33-54 years). The mean duration of symptoms was 35.0 ± 13.7 days (15-60 days). Sixteen (66.7%) out of the 24 eyes had complete resorption of the serous retinal detachment. The mean BCVA was improved from 0.36 ± 0.25 (0.7 to 0.0) to 0.15 ± 0.29 (1.0 to 0.0) (p= 0.028). 16 of the eyes (66.7%) had total resorption of SRF, 6 of them (25.0%) had partial improvement, and 2 (8.3%) had an increase in SRF. There was a significant relationship between change in SRFH and baseline SRFBW (R:- 0.596, p=0.041), and there was also a significant relationship between the change in SRFV and baseline SRFBW (R:0.621, p=0.026). Multiple regression analysis revealed that none of the parameters was independently related to the SRFH change, According to the ROC analyses, the most sensitive factors for having persistent SRF were age (AUC=0.494) and SRFBW (AUC=0.481). In anatomical parameters, it was found that having a defect in the RPE and having a large SRFBW were helpful parameters to determine the tendency of progression to the chronic form of CSC.

Conclusion: The RPE defects and large SRFBW determined by SD-OCT may be useful in predicting the high probability of chronic CSC. Keywords : Acute central serous chorioretinopathy, Spectral-domain optic coherence tomography, Predictive factors, Chronic central serous chorioretinopathy