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Prof. MD, Private Doctor DOI : 10.37845/ret.vit.2023.32.28 Purpose: Polypoidal choroidal vasculopathy (PCV) is a disease characterized by a branching neovascular network and polypoidal lesions typically originating from the internal choroidal vessels, and is a subtype of neovascular age-related macular degeneration (nAMD). It is important to make a differential diagnosis due to high prevalence of PCV in all populations and differing clinical course and treatment from nAMD. Although indocyanine green angiography (ICGA) is considered as gold standard in the diagnosis of PCV, it is an invasive method, impractical, and has limited access in many clinics. Therefore, non-invasive, less time-consuming, reliable and easily reproducible diagnostic methods are needed for diagnosis of PCV. In recent years, it has been suggested that there are typical findings for the diagnosis of PCV on spectral-domain optical coherence tomography (SD-OCT) and color fundus images (CFIs), and that the diagnosis can be made with a very high accuracy without ICGA. In this article, typical CFI and SD-OCT findings for the differential diagnosis of PCV were described. In addition, findings supporting the diagnosis of PCV on other noninvasive imaging modalities such as fundus autofluorescence (FOF) and optical coherence tomography angiography (OCTA) were also noted. Keywords : Branching neovascular network, Color fundus photography, Fundus autofluorescence, Indocyanine green angiography, Optical coherence tomography angiography, Polypoidal choroidal vasculopathy, Polypoidal lesion, Spectral domain optical coherence tomography