Material and Method: This cross-sectional study included patients with unilateral chronic CSCR and age- and sex-matched healthy controls. Subfoveal and peripapillary choroidal thickness (CT) were measured from EDI-OCT images in all participants. The CSCR eyes of the patients with CSCR were assigned into group 1 while healthy eyes of the patients with CSCR into group 2 and the right eyes of healthy controls into group 3. CVI was calculated as the ratio of luminal area to total choroidal area after EDI-OCT images processed using binarization method. The stromal area was calculated by subtracting the luminal area from the total choroidal area.

Results: The study included 18 patients with chronic CSCR and 19 controls. There was no significant difference in mean subfoveal CT, peripapillary CT and CVI values between group 1 and group 2. It was found that subfoveal CT and peripapillary CT values were significantly higher in group 1 and group 2 while peripapillary CVI values were significantly higher in group 1 when group 3. While no significant difference was observed between the submacular CVI values among groups 1, 2 and 3, luminal area and stromal area values were significantly higher in group 1 when compared to groups 2 and 3.

Conclusion: Chronic CSCR can cause both increased vascularization and fluid retention in the stroma in the submacular area. Although this may increase the subfoveal CT, it may not change the submacular CVI values. In the peripapillary choroid, on the other hand, it seems that the luminal area is mainly affected, and the ratio of the increased luminal area to the unaffected stromal area may be explanatory for the high peripapillary CVI. Keywords : Central serous chorioretinopathy, Choroidal thickness, Choroidal vascularity index, Chronic, EDI-OCT