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Department of Ophthalmology, Başakşehir Çam Sakura State Hospital, Istanbul, Türkiye DOI : 10.37845/ret.vit.2024.33.35 Postoperative retinal holes may be located centrally or extrafoveally and may be either full-thickness holes or lamellar hole. We describe a case of a case who had multiple eccentric macular holes (MH) occurring as a consequence of pars plana vitrectomy (PPV) surgery for lamellar MH with epiretinal membrane (ERM). A 65-year-old man who presented to us with progressive right eye vision deficiency. Optical coherence tomography (OCT) examination revealed a lamellar MH with ERM in the right eye and normal in the left eye. We performed PPV surgery in the right eye with internal limiting membrane (ILM) peeling, with 20% sulphur hexafluoride gas endotamponade. At the postoperative second week follow-up, >20 holes MHs were observed in the temporal region of the macula on OCT imaging and wide-field fundus photography. The pathogenesis of macular holes in this study is most consistent with contraction of the remaining edge of ILM. Keywords : Eccentric macular hole, epiretinal membrane, lamellar macular hole, pars plana vitrectomy, internal limiting membrane peeling