Materials and Method: A total of 50 eyes of 50 patients, who were diagnosed with exudative ARMD after the examinations and were administered three doses of 1.25 mg/0.05 ml IVB one month apart, were evaluated prospectively. Specular microscopy was performed to evaluate central corneal thickness, endothelial cell count, percentage of hexagonal cells, and coefficient of variation. Corneal structural parameters measured before IVB and after three doses of IVB were compared.

Results: The average age of the patients participating in the study was 75.08 ± 4.9 years. Statistically significant increase was observed in the central corneal thickness before injection compared to the value after three doses of injection (p = 0.004). While the cell density of the patients was 2406.34 ±2 12.28 (cells/mm²) before the injection, cell density was measured as 2388.70 ± 208.88 (cells/mm²) after three doses of injection. There was no statistically significant increase in pre-injection CV percentage compared to the three dose post-injection value (p = 0.06). While the average HEX percentage of patients before the injection was 45.80 ± 4.83 (%),average HEX percentage after injections was measured at 44.66 ± 4.27 (%). The difference between these two measurements was statistically significant (p = 0.03).

Conclusion: With aging, tight junctions in corneal epithelial and endothelial cells may become more sensitive. IVB injections administered in three consecutive doses may cause changes in corneal endothelial cell morphology by causing sensitized tight junctions to be damaged more easily. Keywords : Exudative type age-related macular degeneration, Intravitreal bevacizumab, Corneal endothelial cell, Specular microscopy