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¹G.O.P. Üniversitesi Tıp Fakültesi Göz Hastalıkları A.D., Tokat, Doç Dr.
²G.O.P. Üniversitesi Tıp Fakültesi, Göz Hast. A.D., Tokat, Yard. Doç. Dr.
³G.O.P. Üniversitesi Tıp Fakültesi, Kadın Doğum Hast. A.D., Tokat, Doç Dr.
⁴G.O.P. Üniversitesi Tıp Fakültesi, Kadın Doğum Hast. A.D., Tokat, Yard. Doç. Dr. Purpose: To asses the effect of menopause on retinal sensitivity using short wave automated perimetric (SWAP) parameters versus standard achromatic automated perimetric (SAP) parameters in premenopausal and postmenopausal healthy women.
Materials and Methods: Left eyes of 32 postmenopausal women and 28 healthy controls with regular menses were randomly included in this study. Subjects were determined to be postmenopausal, based on blood Follicular Stimulating Hormone (FSH), Luteinizing Hormone (LH), Estradiol, Progesterone levels and clinical complaints by the Gynecology and Obstetrics Department. Short wavelength (Blue-on– yellow) automated perimetry (SWAP) and standard achromatic (White-on-white) perimetric analysis (SAP) were performed in both premenopausal and postmenopausal women. Visual field analysis were performed using Humphrey Visual Field Analyser 750i with full threshold, central 30-2 program.
Results: The mean ages of premenopausal and postmenopausal women were significantly different (p=0.001). When the results of SWAP and SAP were analyzed, the mean deviation (MD) values of SAP and SWAP in postmenopausal group were significantly higher than premenopausal group (p=0.019) and there was no significance when the correction was adopted to age. The mean PSD and CPSD value with SWAP were significant (p=0.005; p=0.016), but with SAP were not significant when the postmenopausal group was compared with the premenopausal group (=0.102; p=0.275).
Conclusion: Postmenopausal women demonstrate significant depression in visual field threshold sensitivity with SWAP tests and significant positive correlation between the changes of generalized mean retinal sensitivity in SWAP and estradiol levels. The findings of the present study demonstrated that SWAP tests may be more sensitive to determine sex hormone dependent changes of menopause. Keywords : Menopause, standard-achromatic perimetry, shortwavelength perimetry, estrogen, progesterone