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¹İstanbul Retina Enstitüsü, İstanbul, Uzm. Dr.
²İstanbul Retina Enstitüsü, İstanbul, Doç. Dr.
³İstanbul Retina Enstitüsü, İstanbul, Prof. Dr. Purpose: To evaluate multifocal electroretinographic changes in patients with Stargardt’s disease.
Materials and Methods: Twenty-six eyes of 13 patients with Stargardt’s disease (ages, 16- 53 years) and 19 eyes of 19 normal control subjects were examined. The multifocal electroretinographic first-order kernels were extracted from the responses elicited by 61 standard hexagonal elements of a visual response imaging system. P1 amplitudes and implicit times were analyzed within five concentric ring annuli centered on the fovea. Multifocal electroretinographic P1 response amplitude and implicit times within the central 30º of the retina were compared with those of control group.
Results: P1 amplitudes of the Stargardt patients was lower than that of the normal controls without an overlap of the 5-95% intervals in the ring 1 and 2. P1 amplitudes was lower than normal 25 eyes of Stargardt patients (96%) in the ring 3, 14 eyes (54%) in the ring 4 and 10 eyes (38%) in the ring 5. The peak time was not delayed.
Conclusion: Our results showed that although the macular atrophic area was ophthalmoscopically well demarcated in patients with Stargardt’s disease, the abnormality of retinal function extended beyond the borders of ophthalmoscopic lesions. Keywords : Stargardt’s disease, multifocal electroretinography