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¹Dokuz Eylül Üniversitesi, Göz Hastalıkları A.D., İzmir, Uzm. Dr.
²Dokuz Eylül Üniversitesi, Göz Hastalıkları A.D., İzmir, Prof. Dr. Purpose: To evaluate the retina nerve fibre layer (RNFL) thickness with Heidelberg retinal topography (HRT) and optic coherence tomography (OCT) in patients who were use antimalarial drugs
Materials and Methods: This case-control study included 92 eyes of 46 patients that were on systemic hydroxychloroquine and chloroquine therapy for systemic lupus erythematosus(n=18), discoid lupus erythematosus (n=5), rheumatoid arthritis (n=8), Sjögren’s syndrom (n=9) and connective tissue disorders (n=6). The control group was comprised of 25 female and seven male. Peripapillary RNFL measurements obtained with HRT and OCT were compared between two groups.
Results: Mean age of patient and control groups were 46.8±14.9 and 51.4±9.3 years respectively. RNFL thickness measurement in the patient’s group with HRT at the onset, sixth and 12 th month for the right eye was 0.26±0.06, 0.27±0.05, 0.27±0.05 mm and for the left eye it was 0.27±0.07, 0.28±0.06, 0.26±0.06 mm respectively. RNFL thickness with HRT in the control group for the right and left eye was 0.27±0.09 and 0.25±0.05 mm respectively. Average RNFL thickness measurement in the patient’s group with OCT at the onset, sixth and 12 th month for the right eye was 105.3±12.3, 104.5±11.08, 100.6 ±11.5 µm and for the left eye was 104.8±12.2, 103.9±13.17, 100.0±8.9 µm respectively. In the control group for the right eye and the left eye was 99.5 ±11.5 and 97.12±11.3 µm respectively.
Conclusion: The RNFL thickness measured with both OCT and HRT didn’t change in patients that were on antimalarial drugs therapy during the study course. Keywords : Antimalarial drugs, optic coherence tomography, Heidelberg retinal tomography, retina nerve fibre layer thickness, toxic retinopathy