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¹M.D., Ulucanlar Training and Research Eye Hospital, Ankara/TURKEY
²M.D. Associate Professor, Ulucanlar Training and Research Eye Hospital, Ankara/TURKEY
³M.D. Professor, Ulucanlar Training and Research Eye Hospital, Ankara/TURKEY Purpose: To determine the effect of intravitreal bevacizumab (IVB) injection on visual acuity and central macular thickness (CMT) values in acute central serous chorioretinopathy (CSR) cases.
Materials and Methods: 30 eyes of 30 cases with acute CSR, who had undergone one injection of IVB between January 2009 and December 2011, were included to our retrospective study. Medical records of the cases including best-corrected visual acuity (VA) with Snellen charts, anterior and posterior segment examinations, CMT values measured by optical coherence tomography (OCT) and fundus fluorescein angiography (FA) findings before and after IVB injections were reviewed. Paired-sample t tests were used for statistical analysis.
Results: The mean VA before IVB was 0.73±0.11 (0.4-0.9), while it was 0.86±0.8 (0.7-1.0) at the first month, 0.90±0.9 (0.7-1.0) at the third and 0.89±12 (0.6-1.0) at the sixth month after treatment. The VA values after IVB were statistically significantly higher than the pre-treatment value (p=0.000). But no statistically significant difference was found between the VA values at the first and sixth month after treatment (p=0.109). The mean CMT value was 457.5±68.8 μm before treatment, while it was 318.2±55.8 at the first, 231.1±36.7 at the third and 220.6±63.2 μm at the sixth month after İVB injection. The differences between the mean values of CCT before and after the treatment were statistically significant (p=0.000).
Conclusion: IVB injection was thought to cause rapid recovery of the clinical and FA findings with a decrease in the mean CMT and an increase in the mean VA values in acute CSR cases. Keywords : Acute central serous chorioretinopathy, fundus fluorescein angiography, intravitreal bevacizumab, central macular thickness, optical coherence tomography