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¹M.D. Asistant Professor, Kırıkkale University Faculty of Medicine, Department of Ophthalmology, Kırıkkale/TURKEY
²M.D. Professor, GATA Military Medical Hospital, Eye Clinic, Ankara/TURKEY
³M.D. Professor, Ufuk University Faculyty of Medicine, Department of Pediatrics, Ankara/TURKEY Retinopathy of prematurity (ROP) has been one of the issues about which the specialists have most argued but not compromised to that extent since its first definition. Restricted examination area of the eyes of the premature babies and difficulty of performing examination, and difficulty in achieving sufficient pupil dilatation have precluded the standardization of diagnosis and treatment. Plus disease, defined in 1980 has been used as an important indicator in the diagnosis and treatment of ROP. With a later revision, concepts such as preplus or threshold have been defined, and changes in posterior pole have gained much more importance. Desire of the ROP specialists in using technology towards the diagnosis of plus disease and consensus about the diagnosis has significantly increased in the last 10 years. In this article it was aimed to review the up-to-date studies about the diagnosis and treatment of ROP and plus disease. Keywords : Retinopathy of prematurity, plus disease, threshold disease, treatment