Methods: In this retrospective study fifteen eyes of 13 patients affected by AOFVD, 42 eyes of 42 patients affected by AMD and 27 eyes of 20 healthy individuals were enrolled. AMD eyes was divided into two groups as patients with early and intermediate stage lesions. Fourteen eyes were affected by early AMD, 28 eyes were affected by intermediate AMD. Ophthalmologic examination including color fundus photography, fundus floresein angiography, fundus autofloresence, optic coherence tomography angiography (OCTA) were performed all patients. Outcome measures were superficial (SVD) and deep vessel density (DVD), foveal (FMT)and parafoveal macular thickness (PMT) and foveal avascular zone (FAZ). Statistical analyses were performed using SPSS 16.0 Software (SSPS Inc, Chicago, Illinois, USA). The descriptive statistics were presented as as frequency (percentage) and mean±SD. The normality was checked by Kolmogorov-Smirnov test, but none of the continuous variables were distributed normally (p<0.05). Therefore, Kruskal-Wallis test was used for comparing the variables between the study groups. The relations between the categorical variables was determined by Chi-square test. p<0.05 values were considered as statistically significant result for 5% type-I error.

Results: Foveal and parafoveal SVD were similar in all groups and statistically were not meaningful. When foveal DVD were compared between the groups, there was no difference in the subgroups of AMD with AOFVD separately, while parafoveal DVD was found statistically significant difference only between early- AMD (52.30±3.75 %) and AOFVD (51.77±6.14 %) (p = 0.016). When the groups were compared with AOFVD, there was no statistically significant difference between the groups in terms of FAZ. (p=0.332) FMT was found as significantly higher in the AOFVD group than all other groups (p=0.001). PMT did not differ significantly when compared with AOFVD separately (p=0.175). There were no statistically difference between the AMD stages and healty eyes in regard to DVD.

Conclusion: We demonstrated that parafoveal DVD were significantly increased in patients with AOFVD, after the comparison with intermediate patients with AMD. On the other hand, it was decreased, compared to early AMD. These findings suggest that the pathogenic mechanisms in AOFVD are different from those in AMD that OCTA could be useful in differentiate early stages of these two diseases. In addition, considering the vascular pathologies likely to play a role in the progression of early AMD to intermediate AMD, OCTA can be considered as a useful non-invasive method in early AMD intermediate AMD staging and progression follow-up. Keywords : Adult-onset foveomacular vitelliform dystrophy, age-related macular degeneration, optic coherence tomography angiography, capillary density