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¹S.B Ankara Ulucanlar Göz Hast. Eğt. ve Araş. Hast., Ankara, Uzm. Dr.
²S.B Ankara Ulucanlar Göz Hast. Eğt. ve Araş. Hast., Ankara, Doç. Dr.
³S.B Ankara Ulucanlar Göz Hast. Eğt. ve Araş. Hast., Ankara, Klinik Şefi, Uzm. Dr. A 53-year-old woman with breast cancer for 12 years who was on tamoxifen therapy (20 mg/day) for the last 4 years was referred to our clinic for her yearly ophthalmic examination. Visual acuity was 10/10 in both eyes and no pathology was found in the anterior segment examination. The funduscopy showed small yellow-white crystalline depositions and retinal pigment epithelium changes at the level of the inner retina all around the macula and posterior pole. Fluorescein angiography demonstrated hyperfluorescence due to a window defect and hypofluorescence because of choroidal atrophy and on the late frames dense hyperfluorescence caused by the depositions. Optical coherence tomography showed no macular edema or thickening.
Tamoxifen rarely causes retinopathy in low-dose therapy (20 mg/day). The drug may cause severe changes in fundus appearance and angiography although visual acuity may not be affected. Tamoxifen retinopathy should be kept in mind in the differential diagnosis of diseases causing crystalline deposition and changes in retinal pigment epithelium. Keywords : Tamoxifen, retinopathy, ocular toxicity