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MD, University of Health Sciences, Dışkapı Yıldırım Beyazıt Education and Research Hospital, Department of Ophthalmology, Ankara, Turkey DOI : 10.37845/ret.vit.2021.30.52 The accumulation of cadmium (Cd) in the retina is an unusual condition and it can be seen as a result of long-term occupational exposure. The lesion seen in the retina was considered as a Cd accumulation if there was a high rate of Cd in the blood and urine. The aim of this case report is to describe retinal Cd accumulation due to high-dose Cd exposure in a patient working in a locomotive factory. A male patient, who has a high rate of Cd accumulation in the blood and diagnosed as cadmium-induced polyneuropathy, underwent an examination of the eye. Best-corrected visual acuity, contrast sensitivity, and intraocular pressure measurements were normal. There were retinal pigment epithelium changes and hyper-reflected lesions in optical coherence tomography images and fundus autofluorescence images. Retinal Cd accumulation is unusual, but it can be seen as a result of long-term occupational exposure, especially in the metal industry. Keywords : Hyper-reflectance, Cadmium accumulation, RPE, Heavy metal induced retinopathy