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Ophthalmology Department of Balıkesir University, Medicine School, Balıkesir DOI : 10.37845/ret.vit.2023.32.11 We performed membrane excision and hemorrhage removal via submacular surgery in the second surgical intervention in a patient who received subretinal t-PA due to subretinal hemorrhage following anti-VGEF injection but failed to achieve successful displacement. It was observed ambulatory vision could be achieved in the patient due to severe RPE atrophy within 3 months after surgery. Keywords : Neovascular age-related macular degeneration, subretinal hemorrhage, t-PA, pars plane vitrectomy